Online first

Acta Reumatológica Portuguesa - Online First: 2019-04-23
Original article

Intraarticular injection of platelet-rich plasma in knee osteoarthritis: single versus triple application approach. Pilot study.

Simental-Mendía M, Acosta-Olivo C, Hernández-Rodríguez A, Santos-Santos O, Garza-Castro Sdl, Peña-Martínez V, Vilchez-Cavazos F

Abstract

Objective: To compare the clinical effectiveness of the triple intra-articular injection of platelet-rich plasma (PRP) with respect to the single injection in patients with mild osteoarthritis of the knee. Methods: A total of 35 patients with a clinical and radiographic diagnosis of osteoarthritis grade I and II were analyzed. They were randomized into two groups: single application (18 patients) and triple application (17 patients). Both groups were evaluated using the Visual Analogue Scale (VAS), the Western Ontario and McMaster Universities (WOMAC) index, and the Health Survey 12v2 (SF-12) at baseline and at 6, 12, 24, 36 and 48 weeks post-treatment. Results: Both treatments significantly decreased the level of pain (VAS) (single, from 7.3±2.1 to 4.6±2.7 and triple, from 6.6±2.4 to 0.9±1.4; p