Acta Reumatológica Portuguesa - Online First: 2019-11-04
Intensity of Inflammation as the most important predictor of myocardial involvement in JIA, A 3D Echocardiographic study.
AbstractIntroduction: Myocardial Dysfunction is an important complication in the context of Juvenile Idiopathic Arthritis. Several mechanisms might be involved in induction of myocardial injury in such a disabling disease. Among several factors involved , myocardial inflammation and cardiotoxic drugs were thought to be the most incriminated factors. The aim of this paper was to determine the most important factors that implicated myocardial injury in JIA and to weigh whether the severity of inflammation varies significantly among the several subtypes or not. Methods: Sixty JIA patients as well as sixty, age and surface area, matched controls were subjected to conventional Echocardiography, 3D Speckle tracking and the disease activity was measured as by Juvenile Arthritis Disease Score 27 (JADAS 27) Results: JIA cases showed statistically significant systolic and diastolic dysfunction when compared to controls. Global longitudinal strain (GLS) (index of systolic function) was lower in cases compared to controls (JIA: 16.1±6.7 vs Controls: 23.9±1.4, P