Online first

Acta Reumatológica Portuguesa - Online First: 2020-06-21

Cutaneous vasculitis and granulomatous hepatitis as paradoxical adverse events of Infliximab

Almeida D, Costa E, Neves J, Cerqueira M, Ribeiro A


Biological agents revolutionised the treatment of inflammatory arthropathies. Paradoxical adverse events (PAEs) are rare immunological side effects caused by such agents. The authors report concurrent presentation of two rare PAEs of tumor-necrosis-factor alpha inhibitors (iTNFa) – cutaneous vasculitis and granulomatous hepatitis – in a patient with psoriatic arthritis treated with infliximab and briefly discuss aspects of diagnosis, pathophysiology and management of such events in light of the available evidence.